serotonin [5HT]-4 receptor; 5-hydroxytryptamine receptor 4; 5-HT-4; 5-HT4; serotonin receptor 4 (HTR4)

Function

• one of the several receptors for 5-hydroxytryptamine (serotonin)
• activity of this receptor is mediated by G proteins that stimulate adenylate cyclase (Gs proteins)
• isoform 5-HT4(A) interacts with MAGI2, MPP3, SLC9A3R1 & SNX27 isoforms 1 & 2
• isoform 5-HT4(E) interacts with INADL, NOS1 & SEC23A
• isoform 5-HT4(A) forms a complex containing SLC9A3R1 & EZR (putative)

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane, endosome
• interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 & EZR might target the protein to specialized subcellular regions, such as microvilli

Alternative splicing

named isoforms=7 additional isoforms seem to exist

Expression

• isoform 5-HT4(A) is expressed in ileum, brain, & atrium, but not in the cardiac ventricle

More general terms

• G-protein coupled receptor; serpentine receptor
• serotonin [5HT] receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3360
• OMIM: https://mirror.omim.org/entry/602164
• UniProt: http://www.uniprot.org/uniprot/Q13639.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3360