InaD-like protein (Inadl protein, hINADL, Pals1-associated tight junction protein, protein associated to tight junctions, INADL, PATJ)

Function

• scaffold protein
• may bring different proteins together at cell membrane
• regulation of protein targeting, cell polarity, integrity of tight junctions (putative)
• regulation of surface expression &/or function of ASIC3 in sensory neurons (putative)
• interacts with ASIC3, KCNJ10, KCNJ15, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NLGN2, HTR2A
• forms a ternary complex with MPP5, CRB1, CRB3
• interacts with TJP3/ZO-3, CLDN1/claudin-1
• L27 domain (Maguk recruitment domain)
  • interaction with MPP5 & CRB3, & MPP5 localization to tight junctions

Structure

• L27 domain required for interaction with MPP5 & CRB3, & MPP5 localization to tight junctions
• PDZ domain 6 mediates interaction with the C-terminus of TJP3 & is crucial for localization to the tight junctions
• PDZ domain 8 interacts with CLDN1

Compartment

• localized in the paranodal region of myelinating Schwann cells
• membrane-associated, apical plasma membrane
• localizes to tight junctions in epithelial cells

Alternative splicing

named isoforms=5

Expression

• expressed in bladder, testis, ovary, small intestine, colon, heart, skeletal muscle, pancreas, cerebellum in brain

More general terms

• scaffold protein

Database

• OMIM: https://mirror.omim.org/entry/603199
• UniProt: http://www.uniprot.org/uniprot/Q8NI35.html