glutamate receptor epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B; N-methyl-D-aspartate receptor subunit 3; hNR3; NR3 (GRIN2B, NMDAR2B)
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Function
- NMDA receptor subunit
- high Ca+2 permeability
- voltage-dependent sensitivity to Mg+2
- mediated by glycine
- forms heteromeric channel of:
- found in a complex with GRIN1 & GRIN3B
- found in a complex with GRIN1, GRIN3A & PPP2CB
- interacts with PDZ domains of INADL & DLG4 (putative)
- interacts with MAGI3
- phosphorylation by PKC enhances activity (putative)
Structure
- belongs to the glutamate-gated ion channel (TC 1.A.10) family
Compartment
Expression
- mRNA expressed only in forebrain
- primarily found in the fronto-parieto-temporal cortex & hippocampus pyramidal cells
- lower expression in the basal ganglia
More general terms
References
- ↑ Kutsuwada T, Kashiwabuchi N, Mori H, Sakimura K, Kushiya E, Araki K, Meguro H, Masaki H, Kumanishi T, Arakawa M, et al. Molecular diversity of the NMDA receptor channel. Nature. 1992 Jul 2;358(6381):36-41. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1377365
- ↑ Ghosh A. Neurobiology. Learning more about NMDA receptor regulation. Science. 2002 Jan 18;295(5554):449-51. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11799227
- ↑ UniProt http://www.uniprot.org/uniprot/Q13224.html