glutamate [NMDA] receptor subunit 3B; N-methyl-D-aspartate receptor subtype NR3B (NMDAR3B, GRIN3B)

Function

• NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low Ca+2 permeability & low voltage-dependent sensitivity to Mg+2
• forms heteromeric channel of:
  • zeta subunit (GRIN1)
  • epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D)
  • a 3rd subunit (GRIN3A or GRIN3B)
• does not form functional homomeric channels
• found in a complex containing GRIN1 & GRIN2A

Structure

• belongs to the glutamate-gated ion channel (TC 1.A.10) family

Compartment

• cell membrane, cell junction
• synapse, postsynaptic cell membrane (putative)
• requires GRIN1 for targeting to the plasma membrane

More general terms

• ionotropic receptor subunit

Component of

• NMDA receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1164
• OMIM: https://mirror.omim.org/entry/606651
• UniProt: http://www.uniprot.org/uniprot/O60391.html