glutamate [NMDA] receptor subunit 3A; N-methyl-D-aspartate receptor subtype (NR3A, NMDAR-L, GRIN3A)

Function

• NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low Ca+2 permeability & low voltage-dependent sensitivity to Mg+2
• may play a role in the development of dendritic spines
• may play a role in PPP2CB-NMDAR mediated signaling mechanism
• forms heteromeric channel of
  • zeta subunit (GRIN1)
  • epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D)
  • 3rd subunit (GRIN3A or GRIN3B)
• found in a complex with GRIN1, GRIN2A or GRIN2B &PPP2CB
• probably interacts with PPP2CB
• no complex with PPP2CB is detected when NMDARs are stimulated by NMDA (putative)

Structure

• N-glycosylated (putative)
• belongs to the glutamate-gated ion channel (TC 1.A.10) family

Compartment

• cell membrane, cell junction
• synapse, postsynaptic cell membrane, postsynaptic density
• enriched in post-synaptic plasma membrane & post-synaptic density
• requires GRIN1 for targeting to the plasma membrane

Expression

expressed in fetal brain

More general terms

• ionotropic receptor subunit

Component of

• NMDA receptor

Database

• OMIM: https://mirror.omim.org/entry/606650
• UniProt: http://www.uniprot.org/uniprot/Q8TCU5.html