glutamate receptor epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; hNR2A; NR2A (GRIN2A, NMDAR2A)

Function

• NMDA receptor subunit
• high Ca+2 permeability
• voltage-dependent sensitivity to Mg+2
• activation requires binding of agonist to both types of subunits
• forms heteromeric channel of
  • zeta subunit (GRIN1)
  • epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D)
  • 3rd subunit (GRIN3A or GRIN3B)
• found in a complex with GRIN1 & GRIN3B
• found in a complex with GRIN1, GRIN3A & PPP2CB
• interacts with PDZ domains of AIP1, INADL & DLG4
• presumptive phosphorylation by PKC

Structure

• belongs to the glutamate-gated ion channel (TC 1.A.10) family

Compartment

• cell membrane
• cell junction, synapse, postsynaptic cell membrane

Expression

mRNA widely distributed

More general terms

• glutamate receptor epsilon
• phosphoprotein
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2903
• OMIM: https://mirror.omim.org/entry/138253
• UniProt: http://www.uniprot.org/uniprot/Q12879.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2903