protein phosphatase 2 catalytic subunit beta; phosphatase 2A catalytic subunit, beta isoform (PPP2CB)
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Function
- reversibly methyl esterified on Leu-309
- carboxyl methylation may play a role in holoenzyme assembly
- varies during the cell cycle
- demethylated by PME1 (in vitro)
- phosphorylation of either Thr (by autophosphorylation- activated protein kinase) or Tyr results in inactivation of the phosphatase
- auto-dephosphorylation has been suggested as a mechanism for reactivation
a phosphoprotein + H2O <--> a protein + phosphate
Cofactor:
- binds 1 iron ion per subunit (putative)
- binds 1 Mn+2 per subunit (putative)
Structure
belongs to the PPP phosphatase family, PP-1 subfamily