glutamate receptor epsilon-3; N-methyl D-aspartate receptor subtype 2C; NMDAR2C; NR2C (GRIN2C NMDAR2C)

Function

• NMDA receptor subunit
• confers relative resistance to Mg+2 block
• high Ca+2 permeability
• voltage-dependent sensitivity to Mg+2
• mediated by glycine
• interacts with PDZ domains of INADL & DLG4
• forms heteromeric channel of:
  • zeta subunit (GRIN1)
  • epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D)
  • 3rd subunit (GRIN3A or GRIN3B)

Structure

• belongs to the glutamate-gated ion channel (TC 1.A.10) family

Compartment

• cell membrane
• cell junction, synapse, postsynaptic cell membrane

Expression

• mainly in brain
• predominant expression is in the cerebellum
• also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei & thalamus
• detected in the heart, skeletal muscle & pancreas

More general terms

• glutamate receptor epsilon
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2905
• OMIM: https://mirror.omim.org/entry/138254
• UniProt: http://www.uniprot.org/uniprot/Q14957.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2905