neuroligin-2 (NLGN2 KIAA1366)

Function

• neuronal cell surface protein
• thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins
• seems to play role in formation or maintenance of synaptic junctions
• in vitro, triggers the de novo formation of presynaptic structures
• interacts with neurexin 1-beta, neurexin 2-beta & neurexin 3-beta
• interacts with INADL (putative)
• probably interacts through its C-terminus with DLG4 3rd PDZ domain

Structure

• belongs to the type-B carboxylesterase/lipase family

Compartment

• membrane; single-pass type 1 membrane protein (putative)

More general terms

• neuroligin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57555
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57555
• OMIM: https://mirror.omim.org/entry/606479
• UniProt: http://www.uniprot.org/uniprot/Q8NFZ4.html