neurexin-2-beta; neurexin II-beta (NRXN2)
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Function
- neuronal cell surface protein
- may be involved in cell recognition & cell adhesion
- cytoplasmic C-terminal region binds to CASK
- specific isoforms bind alpha-dystroglycan & neuroligins NLGN1, NLGN2 & NLGN3 (putative)
Structure
- alternative splicing in the laminin G-like domain regulates binding to alpha-dystroglycan
- belongs to the neurexin family
- contains 1 laminin G-like domain
Compartment
membrane Alternative promoter: yes
Alternative splicing
named isoforms=1
Expression
- neurexin-2 beta is more uniformly expressed than neurexin-2 alpha with particularly high levels expressed in the outer layers of the cerebral cortex & cerebellum[3]
More general terms
References
- ↑ Ushkaryov YA et al Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin. Science 257:50 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1621094
- ↑ Hata Y et al Interaction of synaptotagmin with the cytoplasmic domains of neurexins. Neuron 10:307 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8439414
- ↑ 3.0 3.1 Ullrich B et al Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons. Neuron 14:497 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7695896
- ↑ UniProt http://www.uniprot.org/uniprot/P58401.html