neuroligin-3; Gliotactin homolog (NLGN3, KIAA1480, NL3)

Function

• neuronal cell surface protein
• thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins
• may play a role in formation or maintenance of synaptic junctions
• may also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system
• interacts with neurexin 1-beta, neurexin 2-beta & neurexin 3-beta (putative)
• probably interacts through its C-terminus with DLG4/PSD-95 3rd PDZ domain

Structure

• belongs to the type-B carboxylesterase/lipase family

Compartment

• membrane; single-pass type 1 membrane protein (putative)

Alternative splicing

named isoforms=2

Pathology

• defects in NLGN3 may be the cause of
• susceptibility to autism X-linked type 1
• susceptibility to X-linked Asperger syndrome 1

More general terms

• neuroligin
• phosphoprotein

Additional terms

• Asperger syndrome
• autism (autistic spectrum disorder, ASD)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54413
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54413
• OMIM: https://mirror.omim.org/entry/300336
• OMIM: https://mirror.omim.org/entry/300425
• OMIM: https://mirror.omim.org/entry/300494
• UniProt: http://www.uniprot.org/uniprot/Q9NZ94.html