neurexin-1-beta; neurexin I-beta (NRXN1)
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Function
- neuronal cell surface protein
- may be involved in cell recognition & cell adhesion by forming intracellular junctions through binding to neuroligins
- may play a role in formation or maintenance of synaptic junctions
- may mediate intracellular signaling
- the cytoplasmic C-terminal region binds to CASK
- isoforms beta 4b bind neuroligins NLGN1, NLGN2 & NLGN3, alpha- dystroglycan & alpha-latrotoxin (putative)
Structure
- highly O-glycosylated & minor N-glycosylated
- belongs to the neurexin family
- contains 1 laminin G-like domain
Compartment
membrane Alternative promoter: yes
Alternative splicing
named isoforms=1
Expression
- restricted in its distribution to layers II & III of specific cortical regions, thethalamus & parts of the hippocampus[3]
More general terms
References
- ↑ Ushkaryov YA et al Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin. Science 257:50 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1621094
- ↑ Hata Y et al Interaction of synaptotagmin with the cytoplasmic domains of neurexins. Neuron 10:307 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8439414
- ↑ 3.0 3.1 Ullrich B et al Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons. Neuron 14:497 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7695896