neuroligin-1 (NLGN1, KIAA1070)

Function

• neuronal cell surface protein
• thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins
• seems to play role in formation or maintenance of synaptic junctions
• in vitro, triggers the de novo formation of presynaptic structures
• may be involved in specification of excitatory synapses
• interacts with neurexin 1-beta, neurexin 2-beta & neurexin 3-beta
• interacts through its C-terminus with DLG4/PSD-95 3rd PDZ domain
• interacts with AIP1 & PDZRN3 (putative)

Structure

• belongs to the type-B carboxylesterase/lipase family

Compartment

• cell membrane; single-pass type 1 membrane protein (putative)
• cell junction, synapse
• postsynaptic membrane, postsynaptic density (putative)
• enriched in synaptic membranes & clustered in synaptic clefts & postsynaptic densities (putative)

Alternative splicing

named isoforms=2

More general terms

• neuroligin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22871
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:22871
• OMIM: https://mirror.omim.org/entry/600568
• UniProt: http://www.uniprot.org/uniprot/Q8N2Q7.html