serotonin [5HT]-2A receptor; 5-hydroxytryptamine receptor 2A; 5-HT-2A; 5-HT-2; serotonin receptor 2A (HTR2A, HTR2)

Function

• G protein-coupled receptor that activates a PtdIns-Ca+2 second messenger system
• tracheal smooth muscle contraction, bronchoconstriction
• aldosterone production
• interacts with MPDZ, INADL & possibly with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1, AIP1

Structure

• belongs to the G-protein coupled receptor 1 family
• PDZ domain-binding motif is involved in interactions with: INADL, CASK, APBA1, DLG1, DLG4.

Compartment

• localizes to the post-synaptic thickening of axo-dendritic synapses

Polymorphism

• the A allele of SNP rs7997012 in the HTR2A gene confers likelihood of response to SSRIs

Pharmacology

• likely involved in response to SSRI in the treatment of depression
• HTR2A is downregulated by citalopram & probably other SSRIs
• pimavanserin, a selective serotonin 5-HT2A receptor antagonist, is useful for treating psychosis associated with Parkinson's disease

Laboratory

• HTR2A gene mutation
• HTR2A+HTR2C gene mutation

More general terms

• serotonin [5HT]-2 receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3356
• OMIM: https://mirror.omim.org/entry/182135
• UniProt: http://www.uniprot.org/uniprot/P28223.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3356