Ca+2-independent phospholipase-A2 (peroxiredoxin 6, PRDX6, antioxidant protein 2, 1-Cys peroxiredoxin, 1-Cys PRX, acidic calcium-independent phospholipase A2, aiPLA2, non-selenium glutathione peroxidase, NSGPx, 24 kDa protein, liver 2D page spot 40, red blood cells page spot 12)

Function

• role in redox regulation of the cell
• can reduce H2O2 & short chain organic, fatty acid, & phospholipid hydroperoxides
• may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury
• may interact with HTR2A (putative)
• interacts with STH
• active site is the redox-active cys-47 oxidized to cys-SOH
• cys-SOH may rapidly react with a cys-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation
• enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin

2 R'-SH + ROOH <--> R'-S-S-R' + H2O + ROH

Donor + H2O2 <--> oxidized donor + 2 H2O

Structure

• homotetramer
• belongs to the ahpC/TSA family. Rehydrin subfamily

Compartment

• cytoplasm (putative), lysosome
• cytoplasmic vesicle (putative)
• found in lung secretory organelles (putative)

Expression

• bound in virtually all organs with largest amounts in brain, lung, heart, & liver

Pathology

• irreversibly inactivated by overoxidation of cys-47 (to cys-SO(3)H) upon oxidative stress

More general terms

• phospholipase A2; phosphatidylcholine 2-acylhydrolase (PLA2)
• tperoxiredoxin (PRDX)
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9588
• OMIM: https://mirror.omim.org/entry/602316
• UniProt: http://www.uniprot.org/uniprot/P30041.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9588