E3 ubiquitin-protein ligase TRIM32; tripartite motif-containing protein 32; zinc finger protein HT2A; 72 kD Tat-interacting protein (TRIM32, HT2A)

Function

• has an E3 ubiquitin ligase activity
• ubiquitinates DTNBP1 (dysbindin) & promotes its degradation
• protein modification; protein ubiquitination
• ubiquitinated
• interacts with DTNBP1
• self-associates

Structure

• belongs to the TRIM/RBCC family
• contains 1 B box-type Zn+2 finger
• contains 5 NHL repeats
• contains 1 RING-type Zn+2 finger

Compartment

• cytoplasm
• localized in cytoplasmic bodies, often located around the nucleus

Expression

• spleen, thymus, prostate, testis, ovary, intestine, colon & skeletal muscle

Pathology

• defects in TRIM32 are the cause of
  • limb-girdle muscular dystrophy type 2H
  • Bardet-Biedl syndrome type 11
• may play a role in mediating the biological activity of the HIV-1 Tat protein in vivo
  • binds specifically to the activation domain of HIV-1 Tat
  • can also interact with the HIV-2 & EIAV Tat proteins in vivo

More general terms

• tripartite motif-containing protein (trim protein)
• E3 ubiquitin ligase
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22954
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:22954
• OMIM: https://mirror.omim.org/entry/209900
• OMIM: https://mirror.omim.org/entry/254110
• OMIM: https://mirror.omim.org/entry/602290
• UniProt: http://www.uniprot.org/uniprot/Q13049.html