amyloid beta A4 protein-binding family A member 1; neuron-specific X11 protein; neuronal Munc18-1-interacting protein 1; mint-1; adapter protein X11alpha (APBA1, MINT1, X11)

Function

• putative function in synaptic vesicle exocytosis by binding to Munc18-1
• may modulate processing of beta-amyloid precursor protein (APP) & thus formation of beta-APP
• part of a multimeric complex containing Munc18-1 & syntaxin-1
• part of the brain-specific heterotrimeric complex LIN-10/X11-alpha, LIN-2/CASK, & LIN7
• binds to the cytoplasmic domain of amyloid protein (APP)

Structure

• domains
  • N-terminal domain that binds Munc18-1 & LIN-2/CASK
  • a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein
  • two C-terminal PDZ domains thought to attach proteins to the plasma membrane
• contains 2 PDZ domain (DHR domain)s
• contains 1 PID domain

Expression

brain & spinal cord

More general terms

• amyloid beta A4 precursor protein binding family
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=320
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:320
• OMIM: https://mirror.omim.org/entry/602414
• UniProt: http://www.uniprot.org/uniprot/Q02410.html