Crumbs protein homolog 3 (CRB3)

Function

• role in the establishment of cell polarity in mammalian epithelial cells
• regulates the morphogenesis of tight junctions
• interacts with MPP5, PARD6A & INADL

Structure

• PDZ-binding motif is involved in the interactions with PARD6A & MPP5

Compartment

• apical cell membrane, cell junction, tight junction
• localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells

Alternative splicing

named isoforms=2

Expression

• preferentially expressed in epithelial tissues
• expressed at high levels in lung, kidney, retina, colon & mammary glands
• expressed at moderate levels in liver, spleen, pancreas, placenta & prostate

More general terms

• glycoprotein
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BUF7.html