atrophin-1-interacting protein 1; membrane-associated guanylate kinase, WW & PDZ domain-containing protein 2; AIP-1; atrophin-1-interacting protein A; membrane-associated guanylate kinase inverted 2; MAGI-2 (MAGI2, ACVRINP1, AIP1, KIAA0705)

Function

(putative)

• scaffold molecule at synaptic junctions by assembling neurotransmitter receptors & cell adhesion proteins
• role in regulating activin-mediated signaling in neurons
• synergistic with PTEN suppressing AKT1 activation.
• interacts with:
  • via WW domains with DRPLA
  • via 2nd PDZ domain with PTEN unphosphorylated C-terminus
  • via guanylate kinase domain with DLGAP1
  • via PDZ domains with GRIN2A, GRID2 & NLGN1
  • CTNND2, CTNNB1, MAGUIN-1, ACVR2, MADH2 & MADH3
• part of a complex consisiting of: AIP1, ACVR2, ACVR1B & MADH3
• identified in a complex with ACTN4, CASK, IQGAP1, NPHS1, SPTAN1 & SPTBN1
• interacts with DDN

Structure

• belongs to the MAGUK family
• contains 1 guanylate kinase-like domain
• contains 6 PDZ domain (DHR domain)s
• contains 2 WW domains

Compartment

• cell junction, synapse,
• cell membrane; peripheral membrane protein
• membrane-associated in synaptosomes

Alternative splicing

named isoforms=2

Expression

specifically expressed in brain

More general terms

• scaffold protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9863
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9863
• OMIM: https://mirror.omim.org/entry/606382
• UniProt: http://www.uniprot.org/uniprot/Q86UL8.html