activin receptor 2A; activin receptor type IIA; ACTR-IIA; ACTRIIA (ACVR2A, ACVR2)
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Function
- by analogy with the TGF-beta receptor system, it is likely that the type 2 activin receptor is a constitutively active kinase[2]
- phosphorylates type 1 activin receptor which subsequently initiates intracellular signalling[2]
- on ligand binding, forms a receptor complex consisting of two type II & two type I transmembrane serine/threonine kinases
- type II receptors phosphorylate & activate type I receptors which autophosphorylate, then bind & activate SMAD transcriptional regulators
- receptor for activin A, activin B & inhibin A
- interacts with AIP1
- part of a complex consisting of AIP1, ACVR2A, ACVR1B & SMAD3 (putative)
Cofactor: Mg+2 or Mn+2 (putative)
Structure
- belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
- contains 1 protein kinase domain
Compartment
membrane
More general terms
References
- ↑ Matzuk MM et al Different phenotypes for mice deficient in either activins or activin receptor type II. Nature 374:356 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7885474
- ↑ 2.0 2.1 2.2 Smith J Developmental biology. Angles on activin's absence. Nature 374:311 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7885466
- ↑ UniProt http://www.uniprot.org/uniprot/P27037.html
- ↑ CGP resequencing studies http://www.sanger.ac.uk/perl/genetics/CGP/cgp_viewer?action=gene&ln=ACVR2