SMAD protein

Classification

• receptor regulated SMADs (R-SSMADs): SMAD-1, SMAD-2, SMAD-3, SMAD-5, SMAD-8
• inhibitory SMADs (I-SMADs): SMAD-6 & SMAD-7
• common SMAD (co-SMAD): SMAD-4

Function

• role in signal transduction by TGF-beta family proteins & bmp proteins
• DNA binding proteins interacting with SMADs include:
  • foxH1
  • mixer
  • c-jun
  • lef-1/tcf
  • cbfa1, cbfa3
  • vdr
  • oaz
  • hoxc8
• regulated by ubiquitin-proteasomal pathway

Structure

• related to MAD (mothers against decapentaplegic) in Drosophila & Sma in C elegans.

More general terms

• other protein

More specific terms

• smad induced genes/smad gene targets
• SMAD1/MADH1; mothers against decapentaplegic homolog 1; mothers against DPP homolog 1; MAD homolog 1; Mad-related protein 1; SMAD family member 1; SMAD 1; smad1; hSMAD1; transforming growth factor-beta-signaling protein 1; BSP-1; JV4-1; dwarfin A (SMAD...
• SMAD2/MADH2; mothers against decapentaplegic homolog 2; mothers against DPP homolog 2; MAD homolog 2; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; smad2; hSMAD2; JV18-1 (SMAD2, MADH2, MADR2)
• SMAD3/MADH3; mothers against decapentaplegic homolog 3; mothers against DPP homolog 3; MAD homolog 3; Mad3; hMAD-3; SMAD family member 3; SMAD 3; smad3; hSMAD3; JV15-2 (SMAD3, MADH3)
• SMAD4/MADH4; mothers against decapentaplegic homolog 4; mothers against DPP homolog 4; MAD homolog 4; SMAD family member 4; SMAD 4; smad4; hSMAD4; deletion target in pancreatic carcinoma 4 (SMAD4, DPC4, MADH4)
• SMAD5/MADH5; mothers against decapentaplegic homolog 5; mothers against DPP homolog 5; MAD homolog 5; SMAD family member 5; SMAD 5; smad5; hsmad5; JV5-1; dwarfin-C (SMAD5, MADH5)
• SMAD6/MADH6; mothers against decapentaplegic homolog 6; mothers against DPP homolog 6; MAD homolog 6; SMAD family member 6; SMAD 6; smad6; hSMAD6 (SMAD6, MADH6)
• SMAD7/MADH7; mothers against decapentaplegic homolog 7; mothers against DPP homolog 7; MAD homolog 7; SMAD family member 7; SMAD 7; smad7; hSMAD7; mothers against decapentaplegic homolog 8; mothers against DPP homolog 8; MAD homolog 8 (SMAD7, MADH7, MA...
• SMAD9/MADH9; mothers against decapentaplegic homolog 9; mothers against DPP homolog 9; MAD homolog 9; SMAD family member 9; SMAD 9; smad9; Madh6 (SMAD9, MADH6, MADH9)