SMAD5/MADH5; mothers against decapentaplegic homolog 5; mothers against DPP homolog 5; MAD homolog 5; SMAD family member 5; SMAD 5; smad5; hsmad5; JV5-1; dwarfin-C (SMAD5, MADH5)

Function

• transcriptional modulator activated by BMP type 1 receptor kinase
• SMAD5 is a receptor-regulated SMAD (R-SMAD)
• phosphorylated on Ser by BMP type 1 receptor kinase
• ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1
• may form trimers with the co-SMAD SMAD4
• interacts with PEBP2-alpha subunit & SMURF1
• interacts with SUV39H1 & SUV39H2
• interacts (via MH2 domain) with LEMD3

Structure

• belongs to the dwarfin/SMAD family
• contains 1 MH1 (MAD homology 1) domain
• contains 1 MH2 (MAD homology 2) domain

Compartment

• cytoplasm, nucleus
• cytoplasmic in the absence of ligand
• migrates to the nucleus when complexed with SMAD4

Expression

• ubiquitous

More general terms

• SMAD protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4090
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4090
• OMIM: https://mirror.omim.org/entry/603110
• UniProt: http://www.uniprot.org/uniprot/Q99717.html