bone morphogenetic protein 1; BMP-1; mammalian tolloid protein; mTld; procollagen C-proteinase; PCP (BMP1, PCOLC)

Function

• cleaves the C-terminal propeptides of
  • procollagen I
  • procollagen II
  • procollagen III
• induces cartilage & bone formation
• may participate in dorsoventral patterning during early development by cleaving chordin (CHRD)
• cleavage of the C-terminal propeptide at Ala-|-Asp in procollagen I & procollagens II & at Arg-|-Asp in procollagen III
• activity is increased by PCOLCE2

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• belongs to the peptidase M12A family
• contains 5 CUB domains
• contains 2 EGF-like domains

Alternative splicing

• named isoforms=7
• at least some isoforms may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Expression

ubiquitous

Comparative biology

• the Drosophila homolog of BMP-1 is the dorsal-ventral patterning protein tolloid

More general terms

• bone morphogenetic protein (BMP)
• zinc metalloprotease

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=649
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:649
• OMIM: https://mirror.omim.org/entry/112264
• UniProt: http://www.uniprot.org/uniprot/P13497.html