procollagen C-endopeptidase enhancer 2 (procollagen COOH-terminal proteinase enhancer 2, procollagen C-proteinase enhancer 2, PCPE-2, PCOLCE2, PCPE2, UNQ250/PRO287)

Function

• binds to the C-terminal propeptide of procollagen types 1 & 2
• may enhance the cleavage of propeptide by BMP1
• interacts with heparin with high affinity, collagen type 1 or collagen type 2

Structure

• O-glycosylated, contains sialic acid
• contains 2 CUB domains
• contains 1 NTR domain

Compartment

secreted protein

Expression

• expressed in the heart, trabecular meshwork, pituitary gland, bladder, mammary gland, trachea, placenta > brain
• expressed in cartilage

More general terms

• secreted protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/607064
• UniProt: http://www.uniprot.org/uniprot/Q9UKZ9.html