chordin (CHRD)

Function

• dorsalizing factor
• developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) & sequestering them in latent complexes (putative)
• cleaved by BMP1; cleavage participates to dorsoventral patterning during early development (putative)
• interacts with TWSG1 &/or BMP4 (putative)

Structure

• belongs to the chordin family
• contains 4 CHRD domains
• contains 4 VWFC domains

Compartment

secreted (putative)

Alternative splicing

• named isoforms=5
• at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Expression

expressed at the highest level in liver

More general terms

• glycoprotein
• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8646
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8646
• OMIM: https://mirror.omim.org/entry/603475
• UniProt: http://www.uniprot.org/uniprot/Q9H2X0.html