twisted gastrulation protein homolog 1 (TWSG1, TSG, PSEC0250)

Function

• role in dorsoventral axis formation
• antagonizes BMP signaling by forming ternary complexes with CHRD & BMPs, thus preventing BMPs from binding to their receptors
• also has pro-BMP activity, partly mediated by cleavage & degradation of CHRD, which releases BMPs from ternary complexes
• modulates BMP-regulated cartilage development & chondrocyte differentiation
• role in thymocyte development
• interaction with CHRD & BMP4 enhances CHRD/BMP4 complex formation
• interacts with BMP7

Structure

• belongs to the twisted gastrulation protein family
• N-terminal domain is sufficient to interact with BMP4

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

• expressed in brain throughout development

More general terms

• secreted protein

Database

• OMIM: https://mirror.omim.org/entry/605049
• UniProt: http://www.uniprot.org/uniprot/Q9GZX9.html