bone morphogenetic protein 7; BMP-7; osteogenic protein 1; OP-1; eptotermin alfa (BMP7, OP1)

Function

• induces cartilage & bone formation
• may be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis
• role in Ca+2 regulation & bone homeostasis
• several peptides with N-termini starting at positions 293, 300, 315 & 316 are secreted
• interacts with SOSTDC1
• interacts with TWSG1 (putative)

Structure

• homodimer; disulfide-linked
• belongs to the TGF-beta family

Compartment

secreted

Expression

• expressed in the kidney & bladder
• lower expression in the brain
• expressed in the developing eye, brain & ear during embryogenesis

Pharmacology

• available under the name Osigraft (Stryker)
  • indicated in treatment of traumatic tibial fracture with non-union of at least 9 months duration in skeletally mature patients, in cases where autograft has failed or is unfeasible

More general terms

• bone morphogenetic protein (BMP)
• TGF-beta family protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=655
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:655
• OMIM: https://mirror.omim.org/entry/112267
• UniProt: http://www.uniprot.org/uniprot/P18075.html