sclerostin domain-containing protein 1 (ectodermal BMP inhibitor, ectodin, uterine sensitization-associated gene 1 protein, USAG-1, SOSTDC1, USAG1, CDA019)

Function

• role in onset of endometrial receptivity for implantation or sensitization for decidual cell reaction
• enhances Wnt signaling & inhibits TGF-beta signaling
• directly antagonizes activity of BMP2, BMP4, BMP6 & BMP7 (dose-dependent), high affinity interactions

Structure

• belongs to the sclerostin family
• contains 1 CTCK domain (C-terminal cystine knot-like domain)

Compartment

secreted

Expression

expressed in kidney > lung

More general terms

• secreted protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6X4U4.html