bone morphogenetic protein 2; BMP-2; bone morphogenetic protein 2A; BMP-2A (BMP2, BMP2A)

Function

• induces cartilage & bone formation
• interacts with SOSTDC1, GREM2, RGMA, RGMB, RGMC & ASPN

Structure

• homodimer, disulfide-linked
• belongs to the TGF-beta family

Expression

• expressed in lung, spleen colon > heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary, small intestine

Pharmacology

• available under the name Infuse (Medtronic Sofamor Danek)
  • used for treating open tibial shaft fractures

More general terms

• bone morphogenetic protein (BMP)
• TGF-beta family protein

More specific terms

• recombinant bone morphogenic protein-2 (rhBMP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=650
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:650
• OMIM: https://mirror.omim.org/entry/112261
• UniProt: http://www.uniprot.org/uniprot/P12643.html