gremlin-2 (cysteine knot superfamily 1 BMP antagonist 2, protein related to DAN & cerberus, GREM2, CKTSF1B2, DAND3, PRDC)

Function

• cytokine
• inhibits activity of BMP2 & BMP4 (dose-dependent)
• antagonizes BMP4-induced suppression of progesterone production in granulosa cells

Compartment

secreted

More general terms

• cytokine

Additional terms

• gremlin-1 (cysteine knot superfamily 1 BMP antagonist 1, increased in high glucose protein 2, IHG-2, down-regulated in Mos-transformed cells protein, proliferation-inducing gene 2 protein, GREM1, CKTSF1B1, DAND2, DRM, PIG2)

Database

• OMIM: https://mirror.omim.org/entry/608832
• UniProt: http://www.uniprot.org/uniprot/Q9H772.html