asporin (periodontal ligament-associated protein 1, PLAP-1, ASPN, PLAP1, UNQ215/PRO241)

Structure

• belongs to the small leucine-rich proteoglycan (SLRP) family, class I subfamily
• contains 12 LRR repeats (leucine-rich repeats_
• no Ser/Gly dipeptide sequence expected for attachment of O-linked glycosaminoglycans, thus probably not a proteoglycan
• O-linked polysaccharide on 54-Ser is probably mucin type linked to GalNAc
• N-linked glycan at Asn-281 consists of variable structures of GlcNAc, mannose, fucose, HexNAc & hexose

Compartment

extracellular matrix

Expression

• expressed in aorta, uterus > small intestine, heart, liver, bladder, ovary, stomach, adrenal, thyroid, mammary glands > trachea, bone marrow, lung

Pathology

• high expression in osteoarthritic articular cartilage

Polymorphism

• poly-Asp region of ASPN is polymorphic, ranges at least from 11-17 Asp

More general terms

• matrix protein

Database

• OMIM: https://mirror.omim.org/entry/608135
• UniProt: http://www.uniprot.org/uniprot/Q9BXN1.html