mimecan; osteoglycin; osteoinductive factor; OIF (OGN, OIF, SLRR3A)

Function

• induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2

Structure

• N-glycosylated & O-glycosylated
  • O-glycosylated with a core 1 glycan or possibly core 8 glycan
• belongs to the small leucine-rich proteoglycan (SLRP) family, SLRP class III subfamily
• contains 7 LRR repeats (leucine-rich repeats)

Compartment

• secreted, extracellular space, extracellular matrix (putative)

Expression

bone

More general terms

• glycoprotein
• growth factor
• secreted protein
• leucine-rich repeat-containing protein (LRRC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4969
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4969
• OMIM: https://mirror.omim.org/entry/602383
• UniProt: http://www.uniprot.org/uniprot/P20774.html