SMAD4/MADH4; mothers against decapentaplegic homolog 4; mothers against DPP homolog 4; MAD homolog 4; SMAD family member 4; SMAD 4; smad4; hSMAD4; deletion target in pancreatic carcinoma 4 (SMAD4, DPC4, MADH4)

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Function

binds phosphorylated R-SMADs; complex translocates to the nucleus; has intrinsic DNA binding capability[3].

Structure

Compartment

Pathology

More general terms

Component of

References

  1. UniProt http://www.uniprot.org/uniprot/Q13485.html
  2. Izzi L & Attisano L Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation. Oncogene 23:2071-8, 2004 PMID: https://www.ncbi.nlm.nih.gov/pubmed/15021894
  3. 3.0 3.1 Derynck R et al. TGF-beta signaling in tumor suppression and cancer progression. Nature genetics 29:17-129, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11586292
  4. Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/SMAD4ID371.html
  5. GeneReviews http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/SMAD4

Database