ubiquitin carboxyl-terminal hydrolase FAF-X; deubiquitinating enzyme FAF-X; fat facets in mammals; hFAM; fat facets protein-related, X-linked; ubiquitin thiolesterase FAF-X; ubiquitin-specific protease 9, X chromosome; ubiquitin-specific-processing protease FAF-X (USP9X, DFFRX, FAM, USP9)

Function

• deubiquitinase involved both in the processing of ubiquitin precursors & of ubiquitinated proteins
• component of TGF-beta/BMP signaling cascade
• regulates chromosome alignment & segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres
• specifically hydrolyzes both Lys-29- & Lys-33-linked polyubiquitins chains
• specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33
• thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin
• interacts with SMAD4, MARK4, NUAK1 & BIRC5/survivin

Structure

belongs to the peptidase C19 family

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• widely expressed in embryonic & adult tissues
• escapes X-inactivation

More general terms

• ubiquitin C-terminal hydrolase
• phosphoprotein

Additional terms

• ubiquitin (UBCEP2, UBB, UBC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8239
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8239
• OMIM: https://mirror.omim.org/entry/300072
• UniProt: http://www.uniprot.org/uniprot/Q93008.html