MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase-like 1 (MARK4, KIAA1860, MARKL1)

Function

• activated by phosphorylation on Thr-214
• ubiquitinated with Lys-29- & Lys-33-linked polyubiquitins which appear to impede LKB1-mediated phosphorylation
• deubiquitinated by USP9X
• phosphorylated at Thr-214 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase & CAB39

Structure

• belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
• contains 1 KA1 (kinase-associated) domain
• contains 1 protein kinase domain
• contains 1 UBA domain

Alternative splicing

named isoforms=2

Expression

• ubiquitous
• isoform 2 is brain-specific

More general terms

• MAP/microtubule affinity-regulating kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57787
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57787
• OMIM: https://mirror.omim.org/entry/606495
• UniProt: http://www.uniprot.org/uniprot/Q96L34.html