STE20-related adapter protein (STRAD alpha, NY-BR-96 antigen, STRAD, LYK5)

Function

• pseudokinase, protein kinase domain is catalytically inactive (by prediction)
• in complex with CAB39, binds to & activates STK11
• relocates STK11 from nucleus to cytoplasm
• role in STK11-mediated G1 cell cycle arrest

Structure

• contains 1 protein kinase domain (catalytically inactive)

Compartment

nucleus, cytoplasm

Alternative splicing

named isoforms=3

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/608626
• UniProt: http://www.uniprot.org/uniprot/Q7RTN6.html