SMAD2/SMAD4

Function

• phosphorylated SMAD2 binds to SMAD4 & enters the nucleus
• SMAD2/SMAD4 & SMAD3/SMAD4 complexes interact with transcription factors:
  • activating transcription factor 2 (ATF2)
  • CREB-binding protein
  • p300 transcriptional adaptor protein
• SMAD2/SMA4 interacts with forkhead activin signal transducer 2
• sno-N antagonizes TGF-beta signalling through direct interactions with SMAD2/SMAD4 & SMAD3/SMAD4.

More general terms

• molecular complex
• nuclear protein