SMAD3/SMAD4

Function

• phosphorylated SMAD3 binds to SMAD4 & enters the nucleus SMAD2/SMAD4 & SMAD3/SMAD4 complexes interact with transcription factors:
  • activating transcription factor 2 (ATF2)
  • CREB-binding protein
  • p300 transcriptional adaptor protein
• sno-N antagonizes TGF-beta signalling through direct interactions with SMAD2/SMAD4 & SMAD3/SMAD4.

More general terms

• molecular complex
• nuclear protein