ski-like protein; ski-related protein; ski-related oncogene; sno-proto oncogene protein (SKIL, SNO)

Function

• may have regulatory role in cell division or differentiation in response to extracellular signals
• interacts with SMAD2, SMAD3 & RNF111
• antagonizes TGF-beta signalling through direct interactions with SMAD2/SMAD4 & SMAD3/SMAD4

Structure

• belongs to the SKI family

Alternative splicing

• named isoforms=4; SNON, SNOA, SNON2, SNOI

Expression

• SNON & SNOA isoforms are widely expressed
• highest expression is found in skeletal muscle, followed by placenta & lung
• lowest expression in heart, brain & pancreas
• expression of isoform SNOI is restricted to skeletal muscle

More general terms

• proto oncogene protein
• transcription factor (TF)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6498
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6498
• OMIM: https://mirror.omim.org/entry/165340
• UniProt: http://www.uniprot.org/uniprot/P12757.html