Serine/threonine kinase 11-interacting protein (LKB1-interacting protein 1, STK11IP, KIAA1898, LIP1, LKB1IP, STK11IP1)

Function

• may regulate STK11 function by controlling its subcellular localization
• found in a ternary complex composed of STK11, STK11IP & SMAD4
• interacts with STK11 & SMAD4
• phosphorylated

Structure

• belongs to the STK11IP family
• contains 6 LRR repeats (leucine-rich repeats)

Compartment

• cytoplasm
• some cells show granular or punctate expression
• colocalizes with STK11 & SMAD4 in granular or punctate structures

Alternative splicing

named isoforms=2

Notes

uncertain whether Met-1 or Met-12 is the initiator

More general terms

• uncharacterized protein

Database

• OMIM: https://mirror.omim.org/entry/607172
• UniProt: http://www.uniprot.org/uniprot/Q8N1F8.html