SMAD1/MADH1; mothers against decapentaplegic homolog 1; mothers against DPP homolog 1; MAD homolog 1; Mad-related protein 1; SMAD family member 1; SMAD 1; smad1; hSMAD1; transforming growth factor-beta-signaling protein 1; BSP-1; JV4-1; dwarfin A (SMAD1, BSP1, MADH1, MADR1)
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Function
- transcriptional modulator activated by BMP type 1 receptor kinase
- SMAD1 is a receptor-regulated SMAD (R-SMAD)
- SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1
- phosphorylated on Ser by BMP type 1 receptor kinase
- ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1
- interacts with HGS, NANOG & ZCCHC12 (putative)
- may form trimers with another SMAD1 & the co-SMAD SMAD4
- interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), p300, SMURF1, SMURF2 & HOXC8. associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes
- interacts with LBXCOR1.
- interacts (via MH2 domain) with LEMD3
- binding to LEMD3 results in at least a partial reduction of receptor-mediated phosphorylation
- forms a ternary complex with PSMB4 & OAZ1 before PSMB4 is incorporated into the 20S proteasome
Structure
- belongs to the dwarfin/SMAD family
- contains 1 MH1 (MAD homology 1) domain
- contains 1 MH2 (MAD homology 2) domain
Compartment
- cytoplasm, nucleus
- cytoplasmic in the absence of ligand
- migrates to the nucleus when complexed with SMAD4
- co-localizes with LEMD3 at the nucleus inner membrane
Expression
- ubiquitous
- highest expression seen in the heart & skeletal muscle
More general terms
References
- ↑ Derynck R et al Nomenclature: vertebrate mediators of TGFbeta family signals. Cell 87:173, 1996 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8861901
- ↑ Izzi L & Attisano L Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation. Oncogene 23:2071-8, 2004 PMID: https://www.ncbi.nlm.nih.gov/pubmed/15021894
- ↑ UniProt http://www.uniprot.org/uniprot/Q15797.html