ornithine decarboxylase antizyme 1; ODC-Az (OAZ1, OAZ)

Function

• binds to, & destabilizes, ornithine decarboxylase which is then degraded
• also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter
• SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1
• forms a ternary complex with PSMB4 & SMAD1 before PSMB4 is incorporated into the 20S proteasome

Structure

belongs to the ODC antizyme family

Notes

• a ribosomal frameshift occurs between the codons for Ser-68 & Asp-69
• an autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines

More general terms

• ornithine decarboxylase antizyme

Additional terms

• antizyme inhibitor 1; AZI; ornithine decarboxylase antizyme inhibitor (AZIN1, OAZI, OAZIN)
• ornithine decarboxylase 1

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4946
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4946
• OMIM: https://mirror.omim.org/entry/601579
• UniProt: http://www.uniprot.org/uniprot/P54368.html