ornithine decarboxylase 1
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Function
- amine & polyamine biosynthesis
- putrescine biosynthesis via L-ornithine pathway
- putrescine from L-ornithine: step 1/1
L-ornithine <--> putrescine + CO2
Cofactor: pyridoxal phosphate
Structure
- homodimer
- belongs to the orn/Lys/Arg decarboxylase class-II family
Expression
- peaks in G1 prior to DNA synthesis & again in G2/M, eliciting comparable changes in polyamine synthesis
Pathology
- may confer transforming properties to 3T3 cells
More general terms
Additional terms
- antizyme inhibitor 1; AZI; ornithine decarboxylase antizyme inhibitor (AZIN1, OAZI, OAZIN)
- arginine decarboxylase; ADC; ARGDC; ODC-paralogue; ODC-p; ornithine decarboxylase-like protein (ADC KIAA1945 ODCP)
- ornithine decarboxylase antizyme
References
- ↑ Auvinen eta al Nature 360:355 1992
- ↑ Rogers S et al, Amino acids common to rapidly degraded proteins: The PEST hypothesis Science 234:364 1986 (1/2life) PMID: https://www.ncbi.nlm.nih.gov/pubmed/2876518
- ↑ Wikipedia, ornithine decarboxylase entry http://en.wikipedia.org/wiki/ornithine_decarboxylase
- ↑ UniProt http://www.uniprot.org/uniprot/P11926.html
Database
- UniProt: http://www.uniprot.org/uniprot/P11926.html
- OMIM: https://mirror.omim.org/entry/165640
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4953
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4954