smad nuclear-interacting protein 1; FHA domain-containing protein SNIP1 (SNIP1)

Function

• inhibits SMAD2/SMAD3 binding to DNA
• down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding
• involved in the microRNA (miRNA) biogenesis
• degraded by the proteasome upon binding to the SMAD1/OAZ1/PSMB4 complex
• phosphorylated upon DNA damage, probably by ATM or ATR
• binds SMAD4 & CREBBP/EP300
• binds the ADH1/OAZ1/PSMB4 complex
• interacts with RNASEN

Structure

• contains 1 FHA domain

Compartment

• nucleus

Expression

• ubiquitous
• highest expression in cardiac muscle & skeletal muscle

More general terms

• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79753
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79753
• OMIM: https://mirror.omim.org/entry/608241
• UniProt: http://www.uniprot.org/uniprot/Q8TAD8.html