E3 ubiquitin-protein ligase SMURF1; hSMURF1; SMAD ubiquitination regulatory factor 1; SMAD-specific E3 ubiquitin-protein ligase 1 (SMURF1, KIAA1625)

Function

• E3 ubiquitin-protein ligase
• acts as a negative regulator of BMP signaling pathway
• acts by mediating ubiquitination & degradation of SMAD1 & SMAD5 (BMP pathway)
• promotes ubiquitination & subsequent proteasomal degradation of TRAF family members
• protein modification; protein ubiquitination
• ubiquitinated by the SCF(FBXL15) complex at Lys-381 & Lys-383, leading to its degradation by the proteasome
• Lys-383 is the primary ubiquitination site
• interacts with TRAF4
• interacts (via HECT domain) with FBXL15 (via LRR repeats)
• interacts with SMAD7 & TGFBR1
  • SMAD7 recruits SMURF1 to TGFBR1 & regulates TGF-beta receptor degradation

Structure

• contains 1 C2 domain
• contains 1 HECT domain (E6AP-type E3 ubiquitin-protein ligase)
• contains 2 WW domains

Compartment

cytoplasm

Alternative splicing

named isoforms=2; long short

More general terms

• Smad ubiquitination regulatory factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57154
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57154
• OMIM: https://mirror.omim.org/entry/605568
• UniProt: http://www.uniprot.org/uniprot/Q9HCE7.html