tumor necrosis factor (TNF) receptor-associated factor 4; cysteine-rich domain associated with RING & Traf domains protein 1; malignant 62; RING finger protein 83 (TRAF4, CART1, MLN62, RNF83)

Function

• adapter protein & signal transducer
• links members of the TNF receptor family to different signaling pathways
• activation of NF-kappa-B, JNK (putative) apoptosis
• development of respiratory tract

Compartment

cytoplasm, nucleus

Expression

• expressed in epithelial cells of thymus, dendritic cells of lymph node, basal cell layer of epithelia including epidermis, nasopharynx, respiratory tract, salivary gland, esophagus

More general terms

• TRAF
• zinc finger protein

Database

• OMIM: https://mirror.omim.org/entry/602464
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9618
• UniProt: http://www.uniprot.org/uniprot/Q9BUZ4.html