core-binding factor [CBF]-alpha (PEBP2-alpha)

Function

• alpha subunit of core-binding factor
• CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers & promoters, including
  • murine leukemia virus
  • polyomavirus enhancer
  • T-cell receptor enhancers
  • osteocalcin
  • osteopontin
  • bone sialoprotein
  • collagen-1 alpha-1
  • LCK
  • IL-3
  • GM-CSF promoters
    • CBF-alpha binds DNA as a monomer & through the Runt domain
    • DNA-binding is increased by heterodimerization

More general terms

• transcription factor (TF)

More specific terms

• core-binding factor [CBF]-alpha 1; runt-related transcription factor 2; RUNX2; acute myeloid leukemia 3 [AML3] protein; polyomavirus enhancer binding protein 2 alpha A subunit; PEBP2-alpha A; SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-bindin...
• core-binding factor [CBF]-alpha 2; runt-related transcription factor 1; acute myeloid leukemia 1 protein; polyomavirus enhancer binding protein 2 alpha B subunit; PEBP2-alpha B; SL3-3 enhancer factor 1 alpha B subunit;SL3/AKV core-binding factor alpha ...
• core-binding factor [CBF]-alpha 3; runt-related transcription factor 3; acute myeloid leukemia 2 protein; polyomavirus enhancer binding protein 2 alpha C subunit; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit (RUN...

Component of

• core-binding factor (CBF) or polyoma virus enhancer-binding protein-2 (PEBP2)