core-binding factor [CBF]-alpha 3; runt-related transcription factor 3; acute myeloid leukemia 2 protein; polyomavirus enhancer binding protein 2 alpha C subunit; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit (RUNX3, AML2, CBFA3, PEBP2A3)

Function

• CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers & promoters, including
  • murine leukemia virus
  • polyomavirus enhancer
  • T-cell receptor enhancers
  • osteocalcin
  • osteopontin
  • bone sialoprotein
  • collagen-1 alpha-1
  • LCK
  • IL-3
  • GM-CSF promoters
• CBF-alpha binds DNA as a monomer & through the Runt domain
• DNA-binding is increased by heterodimerization
• interacts with TLE1 & SUV39H1

Structure

• heterodimer of CBF-alpha & CBF-beta subunit
  • proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes
• contains 1 Runt domain

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• core-binding factor [CBF]-alpha (PEBP2-alpha)
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:864
• OMIM: https://mirror.omim.org/entry/600210
• UniProt: http://www.uniprot.org/uniprot/Q13761.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=864