core-binding factor [CBF]-beta; polyomavirus enhancer binding protein 2 beta; PEBP2-beta; SL3/AKV core-binding factor beta; SL3-3 enhancer factor 1 beta (CBFB)

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Function

beta subunit of core-binding factor
CBFB enhances DNA binding by RUNX1
heterodimer with RUNX1

Structure

belongs to the CBF-beta family

Compartment

nucleus (putative)

Pathology

chromosomal inversion inv(16)(p13;q22) involving CBFB with MYH11 is associated with AML-M4

More general terms

transcription factor (TF)

Additional terms

AML-M4; acute myelomonocytic leukemia

Component of

core-binding factor (CBF) or polyoma virus enhancer-binding protein-2 (PEBP2)

References

↑ Liu et al, Fusion between transcription factor CBF beta/PEB2 beta and a myosin heavy chain in acute myeloid leukemia. Science 261:1041 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8351518
↑ Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/CBFbID45.html
↑ UniProt http://www.uniprot.org/uniprot/Q13951.html

Database

OMIM: https://mirror.omim.org/entry/121360
UniProt: http://www.uniprot.org/uniprot/Q13951.html
Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=865

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