chromosomal inversion inv(16)(p13.1;q22.1)

Introduction

• inversion inv(16)(p13q22) involving CBFB with MYH11 is associated with AML-M4
  • inversion results in a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2-beta) with the tail region of MYH11
  • the PEPB2-MYH11 fusion protein interacts with HDAC8 & RUNX1

More general terms

• chromosomal inversion